配制水溶性差的藥物
“這種類型的研磨機(jī)通過將介質(zhì)(珠粒)與材料(通常是API)一起機(jī)械移動(dòng)到液體中來操作。 這可以通過攪拌器或通過攪拌容器本身來完成。 珠子可以由各種材料制成; 但是，它們通常是玻璃球，陶瓷，金屬或塑料。 珠粒密度可以在2,500至7,800kg / m 3之間，尺寸在0.1至10mm之間(Kwade和Schwedes 2007)。 閉式攪拌介質(zhì)研磨機(jī)可以垂直或水平布置，并且通常配備有用于冷卻目的的熱護(hù)套。 根據(jù)腔室和攪拌器的幾何形狀，可以區(qū)分三種類型的磨機(jī)，即盤式攪拌器，帶銷針式攪拌器的中間磨機(jī)和環(huán)形間隙幾何形狀(圖4.15)?！?/p>
臥式珠(球)磨機(jī)Dispermat SL表示研磨腔容量為50 mL- 50 l實(shí)驗(yàn)室用臥式研磨機(jī)SL的示意圖
Formulating Poorly Water Soluble Drugs
4.3.2.2 Media (Bead) Wet-Milling
This type of mill operates by mechanically moving media (beads) together with the material (normally the API) in a liquid. This can be done either by means of a stirrer or by agitating the container itself. The beads can be made of various materials; however, they are normally glass spheres, ceramics, metal, or plastic. The bead densities can range between 2,500 and 7,800 kg/m 3 , with sizes between 0.1 and >10 mm (Kwade and Schwedes 2007 ) . Closed stirred media mills can be arranged either vertically or horizontally and are normally equipped with a thermal jacket for cooling purposes. According to the chamber and stirrer geometry, three types of mills can be distinguished, namely a disk stirrer, a medial mill with pin-counter-pin stirrer, and an annular gap geometry (Fig. 4.15 ).”
